“This hearty casserole is a simple and delicious way to use up leftover chicken. My grandma has been making this for as long as I can remember! It’s a staple at family gatherings, and my friends always ask for the recipe. Comforting, cheesy, and topped with fluffy biscuits, it’s a crowd-pleaser you’ll want to make again and again!”
Prep Time
- 15 minutes
Cook Time
- 30 minutes
Total Time
- 45 minutes
Servings
- 6–8 servings
Ingredients
- 2 cups cooked chicken (shredded or cubed)
- 1 can (10.5 oz) cream of chicken soup
- ½ cup sour cream
- 1½ cups shredded cheddar cheese (divided)
- 1 can (16.3 oz) refrigerated biscuits
- ¼ cup milk
- ½ tsp garlic powder
- ½ tsp onion powder
- Salt, to taste
- Pepper, to taste
- 2 tbsp melted butter
- Fresh parsley or chives (optional), for garnish
Instructions
Step 1: Preheat the Oven
- Preheat your oven to 375°F (190°C) . Grease a 9×13-inch baking dish with cooking spray or butter to prevent sticking.
Step 2: Prepare the Filling
- In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, 1 cup of shredded cheddar cheese , garlic powder, onion powder, salt, and pepper. Stir until well combined.
- Spread the mixture evenly into the prepared baking dish.
Step 3: Prepare the Biscuit Topping
- Open the can of refrigerated biscuits and separate them. Cut each biscuit into quarters or halves, depending on how large you’d like the topping pieces.
- In a small bowl, toss the biscuit pieces with the milk and melted butter until they’re evenly coated. This will help them bake up golden and crispy.
- Sprinkle the remaining ½ cup of shredded cheddar cheese over the chicken filling in the baking dish.
- Arrange the buttery biscuit pieces evenly over the top of the casserole.
Step 4: Bake the Casserole
- Place the baking dish in the preheated oven and bake for 25–30 minutes , or until the biscuits are golden brown and the filling is bubbly.
Step 5: Garnish and Serve
- Remove the casserole from the oven and let it cool for 5 minutes before serving.
- Garnish with fresh parsley or chives for a pop of color and freshness, if desired.
- Serve warm and enjoy this comforting, cheesy casserole as a main dish or side!
Pro Tips
- Leftover Chicken: Use rotisserie chicken, grilled chicken, or any leftover cooked chicken for convenience.
- Cheese Swap: Substitute cheddar cheese with mozzarella, Monterey Jack, or a blend of cheeses for a different flavor profile.
- Add Veggies: Mix in diced carrots, peas, or celery into the filling for added nutrition and texture.
- Make Ahead: Assemble the casserole up to a day in advance, cover, and refrigerate. Bake as directed, adding 5–10 minutes to the cooking time if starting cold.
- Storage: Store leftovers in an airtight container in the refrigerator for up to 3 days . Reheat in the oven or microwave.
Nutrition Facts (Per Serving, based on 8 servings)
- Calories: 420
- Protein: 22g
- Carbohydrates: 35g
- Fat: 22g
- Fiber: 2g
- Sugar: 6g
Note: Nutrition values are approximate and may vary based on specific ingredients used.
Why You’ll Love This Recipe
This Chicken Biscuit Casserole is a comforting, one-dish wonder that’s perfect for busy weeknights or feeding a crowd. The creamy chicken filling is rich and satisfying, while the buttery biscuit topping adds a delightful crunch and softness. It’s a versatile dish that’s easy to customize and always a hit at family gatherings.
Ready to make this classic casserole? Grab your ingredients and get ready to enjoy a warm, cheesy, and biscuit-topped meal—it’s comfort food at its finest!
